8th Conference of Young Chemists of Serbia

Belgrade, Serbia – At the 8th Conference of Young Chemists of Serbia, held in Belgrade on October 29, 2022, the EMOS research group presented research on the toxicity of nadolol, a widely used beta-blocker, and its photodegradation products. This study marks a significant step in understanding the environmental and health impacts of pharmaceutical residues. The title of the study was Toxicity assessment of nadolol and its photodegradation mixtures using mammalian cell lines by Andrijana Vukojević, Dragana Četojević-Simin, Maria Savanović and Sanja J. Armaković. The results were presented in the form of a poster, “defended” by Andrijana Vukojević.

Andrijana at 8th conference of young chemists

Our investigation centered around the assessment of nadolol’s toxicity, particularly after its exposure to light, which leads to photodegradation. Using mammalian cell lines, we evaluated the biological effects of both nadolol and its degradation products. This approach is critical in identifying potential risks associated with pharmaceutical compounds that persist in the environment. The presence of pharmaceuticals like nadolol in water sources is a growing concern. Their degradation products can sometimes be more harmful than the original compounds. By understanding the toxicity profile of these substances, we can better assess their impact on human health and the environment.

Our methodology involved a series of toxicity assays using various mammalian cell lines. These assays are designed to reveal the cytotoxic effects of both nadolol and its photodegradation byproducts. The results of these tests provide vital insights into the safety profile of these compounds. The findings of our study have significant implications. They contribute to the body of knowledge necessary for developing guidelines and policies to manage pharmaceutical waste effectively. Moreover, they highlight the need for continued research into the environmental fate and impact of commonly used drugs.